What are the treatments for COVID-19?
Updated: March 19, 2020 18:57 Chinese Center for Disease Control and Prevention

Suspected and confirmed cases should be isolated and treated in designated hospitals with effective isolation and protective conditions, and suspected cases should be isolated in a single room. Multiple confirmed cases can be admitted to the same ward, and critical cases should be admitted to ICU as soon as possible.

General treatments: patients should rest on the bed and receive strengthened supportive care to ensure sufficient energy intake; attention should be paid to water and electrolyte balance to maintain the stability of the internal environment, and vital signs and finger oxygen saturation should be closely monitored.

Complete blood count, urinalysis, CRP, biochemical indicators (liver enzyme, myocardial enzyme, renal function, etc.), blood coagulation function, arterial blood gas analysis, chest imaging should be monitored according to the conditions of the cases. Cytokines testing should be performed if conditions permit.

Effective oxygen therapy measures should be provided in time, including nasal cannula, oxygen masks and high-flow nasal cannula oxygen therapy. Mixing hydrogen with inhaled oxygen (H2 / O2: 66.6% / 33.3%) can be used if it is available.

Anti-virus treatment: doctors may administer atomization inhalation of Interferon-α (for adults: 5 million U or equivalent dose, added with 2 ml sterile injection water, atomization inhalation twice a day), Lopinavir/ Ritonavir (for adults: 200mg/50mg per pill, 2 pills per serving, twice a day, the course of treatment should not exceed 10 days), Ribavirin (it is recommended to use it in combination with Interferon-α or Lopinavir/ Ritonavir, for adults 500mg each injection, iv. two to three times a day, the course of treatment should not exceed 10 days). Chloroquine phosphate (for adults (18-65 years old): if weight >50kg, 500 mg each time, twice a day for 7 days; if weight <50kg, 500 mg each time and twice a day on the first and second days, 500 mg each time and once a day for the third to seventh days) and Arbidol (for adults: 200 mg, three times a day, the course of treatment should not exceed 10 days).

Attention should be paid to adverse reactions of the above medications, contraindications (such as chloroquine is contraindicated in patients with heart disease), and interaction with other medications. The efficacy of the tested medications currently should be further evaluated in clinical applications. It is not recommended to use 3 or more antiviral medications at the same time, and the use of related drugs should be stopped when there are intolerable side effects. For the treatment of infected pregnant women, we should calculate the gestational age, choose medications that have less impact on the fetus as much as possible, and consider whether to treat after pregnancy termination, followed by adequately informing the patients.

Anti-bacterial treatment: avoid inappropriate use of antibiotics, especially the combination with broad-spectrum antibiotics.

(Reference: Diagnosis and Treatment Protocol for COVID-19 (Trial Version 7) issued by the General Office of the National Health Commission and the Office of the National Administration of Traditional Chinese Medicine)

Source:Chinese Center for Disease Control and Prevention

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